Abstract
The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.
Original language | English |
---|---|
Pages (from-to) | 91-120 |
Number of pages | 30 |
Journal | Controlled clinical trials |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1999 |
Keywords
- Albuterol
- Allergens
- Anti-inflammatory agents
- Atopy
- Bronchial provocation test
- Bronchodilator agents
- Budesonide
- Childhood asthma
- Clinical trials
- Environmental exposure
- Glucocorticoids
- Growth
- Inhaled bronchodilator
- Nedocromil
- Psychological test
- Spirometry
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Childhood Asthma Management Program Research Group (1999). The childhood asthma management program (CAMP): Design, rationale, and methods. Controlled clinical trials, 20(1), 91-120. https://doi.org/10.1016/S0197-2456(98)00044-0
Childhood Asthma Management Program Research Group. / The childhood asthma management program (CAMP) : Design, rationale, and methods. In: Controlled clinical trials. 1999 ; Vol. 20, No. 1. pp. 91-120.
@article{74ea60ef9c0d47009b1b1cc316c15f61,
title = "The childhood asthma management program (CAMP): Design, rationale, and methods",
abstract = "The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.",
keywords = "Albuterol, Allergens, Anti-inflammatory agents, Atopy, Bronchial provocation test, Bronchodilator agents, Budesonide, Childhood asthma, Clinical trials, Environmental exposure, Glucocorticoids, Growth, Inhaled bronchodilator, Nedocromil, Psychological test, Spirometry",
author = "{Childhood Asthma Management Program Research Group} and Shapiro, {Gail G.} and DuHamel, {Thomas R.} and Wighton, {Timothy G.} and Tamara Chinn and Bierman, {C. Warren} and Furukawa, {Clifton T.} and Altman, {Leonard C.} and Virant, {Frank S.} and Williams, {Paul V.} and Minotti, {Dominick A.} and Kennedy, {Michael S.} and Becker, {Jonathan W.} and Chris Reagan and Heather Eliassen and Dan Crawford and Babi Hammond and Grace Strodtbeck and Marian Sharpe and Scott Weiss and Dirk Greineder and Walter Torda and Martha Tata and Peter Barrant and Anthony DeFilippo and Mary Grace and Stephanie Haynes and Margaret Higham and Susan Kelleher and Jay Koslof and Nancy Madden and Dana Mandel and Agnes Martinez and Jean McAuliffe and Paola Pacella and Paula Parks and Anne Plunkett and Kay Seligsohn and June Traylor and {Van Horn}, Melissa and Janice Ware and Carolyn Wells and Ann Whitman and Joe Reisman and Ian MacLusky and Henry Levison and Anita Hall and Yola Benedet and Jennifer Chay and Michelle Collinson and Jane Finlayson-Kulchin and Kenneth Gore and Melody Miki and Ren{\'e}e Sananes and Adkinson, {N. Franklin} and Peyton Eggleston and Karen Huss and Leslie Plotnick and Margaret Pulsifer and Cynthia Rand and Barbara Wheeler and Nancy Bollers and Kimberly Hyatt and Betsy Leritz and Mildred Pessaro and Stephanie Philips and Stanley Szefler and Nelson, {Harold S.} and D. Sundstr{\"o}m and Bruce Bender and Kristin Brelsford and Melanie Gleason and Joseph Hassell and Caroline Hendrickson and Irvin, {Charles G.} and Tara Junk and Andrew Liu and Joseph Spahn and White, {Michael P.} and Jeryl Feeley and Jessyca Bridges and Jody Ciacco and Michael Eltz and Michael Flynn and Marcia Hefner and Daniel Hettleman and Jeffrey Jacobs and Alan Kamada and Sai Nimmagadda and Kendra Sandoval and Jessica Sheridan and Trella Washington and Eric Willcutt and Robert Zeiger and Anthony Horner and Noah Friedman and Al Jalowayski and Alan Lincoln and Mellon, {Michael H.} and Michael Schatz and Kathleen Harden and Galbreath, {Linda L.} and Ellen Hanson and Jenson, {Elaine M.} and Shirley King and Brian Lopez and Michaela Magiari and Nelle, {Catherine A.} and Senia Pizzo and Eva Rodriquez and Easton, {James G.} and Kathleen Mostafa and Avraham Moscona and Karen Sandoval and Bennie McWilliams and Robert Annett and Kelly, {H. William} and Mary Spicher and Diane Becker and Selda Bereket and Marisa Braun and Shannon Bush and David Hunt and Margaret Moreshead and Barbara Ortega and Strunk, {Robert C.} and Bloomberg, {Gordon R.} and Corry, {James M.} and Smith, {Thomas F.} and Ellen Albers and Bernadette Davantes and Gregg Belle and Marisa Dolinsky and Fisher, {Edwin B.} and Gaioni, {Stephen J.} and Emily Glynn and Cathy Herman and Debra Kemp and Claire Lawhon and Sharon Meltzer and Cynthia Moseid and Tina Oliver-Welker and Denise Rodgers and Carl Turner and White, {Deborah K.} and Mary Caesar and Richardson, {Diana S.} and Elizabeth Ryan and Sylvia, {Susan C.} and Reuben Cherniack and James Tonascia and Curtis Meinert and Debra Amend-Libercci and Patricia Belt and Karen Collins and Betty Collison and Christopher Dawson and John Dodge and Michele Donithan and Dawn Easton and Vera Edmonds and Cathleen Ewing and Judith Harle and Robert Huffman and Liang, {Kung Yee} and Jill Meinert and Deborah Nowakowski and Rosetta Owens and Michael Smith and Alice Sternberg and {Van Natta}, Mark and Robert Wise and Robert Rice and Bob Hughes and Tom Lynch and Sarma Vadlamani and Hamilton, {Robert G.} and Carol Schatz and Jack Wisenauer and Harbeck, {Ronald J.} and Rhonda Emerick and Brian Watson and Cindi Culkin and Sarah Oliver and Lung, {Colleen Lum} and Ann Mullen and Virginia Taggart and Pamela Randall and Paul Albert and Suzanne Hurd and James Kiley and Margaret Wu and Sydney Parker and William Letvenko and William Repko and Rolland Poust and David Herold and Dennis Elbert and Howard Eigen and Michelle Cloutier and John Connett",
note = "Publisher Copyright: {\textcopyright} Elsevier Science Inc. 1999.",
year = "1999",
month = feb,
doi = "10.1016/S0197-2456(98)00044-0",
language = "English",
volume = "20",
pages = "91--120",
journal = "Controlled clinical trials",
issn = "0197-2456",
number = "1",
}
Childhood Asthma Management Program Research Group 1999, 'The childhood asthma management program (CAMP): Design, rationale, and methods', Controlled clinical trials, vol. 20, no. 1, pp. 91-120. https://doi.org/10.1016/S0197-2456(98)00044-0
The childhood asthma management program (CAMP): Design, rationale, and methods. / Childhood Asthma Management Program Research Group.
In: Controlled clinical trials, Vol. 20, No. 1, 02.1999, p. 91-120.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - The childhood asthma management program (CAMP)
T2 - Design, rationale, and methods
AU - Childhood Asthma Management Program Research Group
AU - Shapiro, Gail G.
AU - DuHamel, Thomas R.
AU - Wighton, Timothy G.
AU - Chinn, Tamara
AU - Bierman, C. Warren
AU - Furukawa, Clifton T.
AU - Altman, Leonard C.
AU - Virant, Frank S.
AU - Williams, Paul V.
AU - Minotti, Dominick A.
AU - Kennedy, Michael S.
AU - Becker, Jonathan W.
AU - Reagan, Chris
AU - Eliassen, Heather
AU - Crawford, Dan
AU - Hammond, Babi
AU - Strodtbeck, Grace
AU - Sharpe, Marian
AU - Weiss, Scott
AU - Greineder, Dirk
AU - Torda, Walter
AU - Tata, Martha
AU - Barrant, Peter
AU - DeFilippo, Anthony
AU - Grace, Mary
AU - Haynes, Stephanie
AU - Higham, Margaret
AU - Kelleher, Susan
AU - Koslof, Jay
AU - Madden, Nancy
AU - Mandel, Dana
AU - Martinez, Agnes
AU - McAuliffe, Jean
AU - Pacella, Paola
AU - Parks, Paula
AU - Plunkett, Anne
AU - Seligsohn, Kay
AU - Traylor, June
AU - Van Horn, Melissa
AU - Ware, Janice
AU - Wells, Carolyn
AU - Whitman, Ann
AU - Reisman, Joe
AU - MacLusky, Ian
AU - Levison, Henry
AU - Hall, Anita
AU - Benedet, Yola
AU - Chay, Jennifer
AU - Collinson, Michelle
AU - Finlayson-Kulchin, Jane
AU - Gore, Kenneth
AU - Miki, Melody
AU - Sananes, Renée
AU - Adkinson, N. Franklin
AU - Eggleston, Peyton
AU - Huss, Karen
AU - Plotnick, Leslie
AU - Pulsifer, Margaret
AU - Rand, Cynthia
AU - Wheeler, Barbara
AU - Bollers, Nancy
AU - Hyatt, Kimberly
AU - Leritz, Betsy
AU - Pessaro, Mildred
AU - Philips, Stephanie
AU - Szefler, Stanley
AU - Nelson, Harold S.
AU - Sundström, D.
AU - Bender, Bruce
AU - Brelsford, Kristin
AU - Gleason, Melanie
AU - Hassell, Joseph
AU - Hendrickson, Caroline
AU - Irvin, Charles G.
AU - Junk, Tara
AU - Liu, Andrew
AU - Spahn, Joseph
AU - White, Michael P.
AU - Feeley, Jeryl
AU - Bridges, Jessyca
AU - Ciacco, Jody
AU - Eltz, Michael
AU - Flynn, Michael
AU - Hefner, Marcia
AU - Hettleman, Daniel
AU - Jacobs, Jeffrey
AU - Kamada, Alan
AU - Nimmagadda, Sai
AU - Sandoval, Kendra
AU - Sheridan, Jessica
AU - Washington, Trella
AU - Willcutt, Eric
AU - Zeiger, Robert
AU - Horner, Anthony
AU - Friedman, Noah
AU - Jalowayski, Al
AU - Lincoln, Alan
AU - Mellon, Michael H.
AU - Schatz, Michael
AU - Harden, Kathleen
AU - Galbreath, Linda L.
AU - Hanson, Ellen
AU - Jenson, Elaine M.
AU - King, Shirley
AU - Lopez, Brian
AU - Magiari, Michaela
AU - Nelle, Catherine A.
AU - Pizzo, Senia
AU - Rodriquez, Eva
AU - Easton, James G.
AU - Mostafa, Kathleen
AU - Moscona, Avraham
AU - Sandoval, Karen
AU - McWilliams, Bennie
AU - Annett, Robert
AU - Kelly, H. William
AU - Spicher, Mary
AU - Becker, Diane
AU - Bereket, Selda
AU - Braun, Marisa
AU - Bush, Shannon
AU - Hunt, David
AU - Moreshead, Margaret
AU - Ortega, Barbara
AU - Strunk, Robert C.
AU - Bloomberg, Gordon R.
AU - Corry, James M.
AU - Smith, Thomas F.
AU - Albers, Ellen
AU - Davantes, Bernadette
AU - Belle, Gregg
AU - Dolinsky, Marisa
AU - Fisher, Edwin B.
AU - Gaioni, Stephen J.
AU - Glynn, Emily
AU - Herman, Cathy
AU - Kemp, Debra
AU - Lawhon, Claire
AU - Meltzer, Sharon
AU - Moseid, Cynthia
AU - Oliver-Welker, Tina
AU - Rodgers, Denise
AU - Turner, Carl
AU - White, Deborah K.
AU - Caesar, Mary
AU - Richardson, Diana S.
AU - Ryan, Elizabeth
AU - Sylvia, Susan C.
AU - Cherniack, Reuben
AU - Tonascia, James
AU - Meinert, Curtis
AU - Amend-Libercci, Debra
AU - Belt, Patricia
AU - Collins, Karen
AU - Collison, Betty
AU - Dawson, Christopher
AU - Dodge, John
AU - Donithan, Michele
AU - Easton, Dawn
AU - Edmonds, Vera
AU - Ewing, Cathleen
AU - Harle, Judith
AU - Huffman, Robert
AU - Liang, Kung Yee
AU - Meinert, Jill
AU - Nowakowski, Deborah
AU - Owens, Rosetta
AU - Smith, Michael
AU - Sternberg, Alice
AU - Van Natta, Mark
AU - Wise, Robert
AU - Rice, Robert
AU - Hughes, Bob
AU - Lynch, Tom
AU - Vadlamani, Sarma
AU - Hamilton, Robert G.
AU - Schatz, Carol
AU - Wisenauer, Jack
AU - Harbeck, Ronald J.
AU - Emerick, Rhonda
AU - Watson, Brian
AU - Culkin, Cindi
AU - Oliver, Sarah
AU - Lung, Colleen Lum
AU - Mullen, Ann
AU - Taggart, Virginia
AU - Randall, Pamela
AU - Albert, Paul
AU - Hurd, Suzanne
AU - Kiley, James
AU - Wu, Margaret
AU - Parker, Sydney
AU - Letvenko, William
AU - Repko, William
AU - Poust, Rolland
AU - Herold, David
AU - Elbert, Dennis
AU - Eigen, Howard
AU - Cloutier, Michelle
AU - Connett, John
N1 - Publisher Copyright:© Elsevier Science Inc. 1999.
PY - 1999/2
Y1 - 1999/2
N2 - The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.
AB - The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.
KW - Albuterol
KW - Allergens
KW - Anti-inflammatory agents
KW - Atopy
KW - Bronchial provocation test
KW - Bronchodilator agents
KW - Budesonide
KW - Childhood asthma
KW - Clinical trials
KW - Environmental exposure
KW - Glucocorticoids
KW - Growth
KW - Inhaled bronchodilator
KW - Nedocromil
KW - Psychological test
KW - Spirometry
UR - http://www.scopus.com/inward/record.url?scp=0033012176&partnerID=8YFLogxK
U2 - 10.1016/S0197-2456(98)00044-0
DO - 10.1016/S0197-2456(98)00044-0
M3 - Article
C2 - 10027502
AN - SCOPUS:0033012176
SN - 0197-2456
VL - 20
SP - 91
EP - 120
JO - Controlled clinical trials
JF - Controlled clinical trials
IS - 1
ER -
Childhood Asthma Management Program Research Group. The childhood asthma management program (CAMP): Design, rationale, and methods. Controlled clinical trials. 1999 Feb;20(1):91-120. doi: 10.1016/S0197-2456(98)00044-0